Hygienic-medical relevance of antibiotic-resistant pathogens in raw water (HyReKa)

In recent years, antibiotic resistances have become increasingly significant in the area of hygienic parameters. As part of the HyReKA project, TZW is conducting extensive research on the presence of antibiotic-resistant pathogens and antibiotic resistance genes in raw water.

Infections caused by resistant bacteria for which conventional antibiotics no longer work are becoming increasingly common. In consequence of antibiotic use in human and veterinary medicine resistances spread in the environment during the last years.

In this large-scale joint project, the dissemination of resistant pathogens via waste water from hospitals, communal areas, animal fattening farms and abattoirs and from airports should be investigated and suitable counterstrategies developed. The results should help to better identify and avoid the risk of multi-resistant bacteria spreading.

As part of the HyReKA project, TZW is involved with detecting antibiotic-resistant bacteria and antibiotic resistance genes in raw water. Together with the partners, culture-based and molecular biological detection methods were standardised and subsequently used for monitoring. The use of molecular biological microbial source tracking tools is also tested to determine the origin of antibiotic resistances.


Stange C., Tiehm A.: Verhalten von Antibiotika-Resistenzgenen bei der Trinkwasseraufbereitung. Veröffentlichungen aus dem Technologiezentrum Wasser, ISSN 1434-5765, TZW-Band 76 (2017)

Stange C.,Sidhu J.P.S.,Tiehm A.,Toze S.: Antibiotic resistance and virulence genes in coliform water isolates. International Journal of Hygiene and Environmental Health 219: 823-831 (2016) DOI.org/10.1016/j.ijheh.2016.07.015

Stoll C., Sidhu J.P.S., Tiehm A., Toze S.: Prevalence of clinically relevant antibiotic resistance genes in surface water samples collected from Germany and Australia.
Environmental Science & Technology 46: 9716-9726 (2012) DOI.org/10.1021/es302020s

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